Hi there. I started a thread a while back about my 410, which was giving me grief. I ended up going through a lot of time-consuming steps (going from 10.4.11 on my pre-Intel IMac to 10.3.9, reloading the corresponding M-Audio driver, not getting good results... Finally, after putting 10.4.11 back on, I began trying each of the drivers, to see whether one might work better than others. And for some reason, a recent one, maybe even the one I had on originally, worked. I can't tell you specifically which it was, or why it suddenly worked, but it did. The tech support suggested waiting for the driver update, though they couldn't say whether it would be released this week, or at earliest in the fall. Yeah right.
Since then, I had a power interruption, which seems to have caused bigger problems, beside frying my hard-drive and blowing a nice pair of headphones, which I wasn't wearing at the time. So I'm using a temporary Presonus Firebox, and it has no issues at all (so far). I almost hope the M-Audio folks decide my 410 is beyond repair, even though it's past its warranty date....
I had that unit for one year, and had problems with drivers at least 3 or 4 times. M-Audio won't be getting more of my business.